Tag |
Content |
Uniprot Accession |
Q549C9_MOUSE; Q549C9
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MiCroKit ID |
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Entrez ID |
22059
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Genbank Protein ID |
NP_035770.2; XP_006533220.1; XP_006533221.1
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Genbank Nucleotide ID |
NM_011640.3; XM_006533157.1; XM_006533158.1
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Protein Name |
Cellular tumor antigen p53 |
Gene Name |
Trp53; p53; mCG_20908 |
Organism |
Mus musculus (Mouse); NCBI Taxa ID=
10090 |
Localization |
Localization |
Evidence |
Orthologs |
Centrosome |
Predicted from orthologs |
(View/Close)
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Organism | Accession | Localization | Identity | E-value | Score |
Homo sapiens (Human) | P04637 |
Centrosome | 77.35% | 3e-171 | 598 | |
Functional Description |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the (View all)Functional Description
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity).
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PTM Count: 0
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Sequence (Fasta) | MTAMEESQSD ISLELPLSQE TFSGLWKLLP PEDILPSPHC MDDLLLPQDV EEFFEGPSEA LRVSGAPAAQ DPVTETPGPV 80 APAPATPWPL SSFVPSQKTY QGNYGFHLGF LQSGTAKSVM CTYSPPLNKL FCQLAKTCPV QLWVSATPPA GSRVRAMAIY 160 KKSQHMTEVV RRCPHHERCS DGDGLAPPQH LIRVEGNLYP EYLEDRQTFR HSVVVPYEPP EAGSEYTTIH YKYMCNSSCM 240 GGMNRRPILT IITLEDSSGN LLGRDSFEVR VCACPGRDRR TEEENFRKKE VLCPELPPGS AKRALPTCTS ASPPQKKKPL 320 DGEYFTLKIR GRKRFEMFRE LNEALELKDA HATEESGDSR AHSSYLKTKK GQSTSRHKKT MVKKVGPDSD Fasta Sequence
>Q549C9|Trp53; p53; mCG_20908|Mus musculus (Mouse) MTAMEESQSDISLELPLSQETFSGLWKLLPPEDILPSPHCMDDLLLPQDVEEFFEGPSEALRVSGAPAAQDPVTETPGPVAPAPATPWPLSSFVPSQKTYQGNYGFHLGFLQSGTAKSVMCTYSPPLNKLFCQLAKTCPVQLWVSATPPAGSRVRAMAIYKKSQHMTEVVRRCPHHERCSDGDGLAPPQHLIRVEGNLYPEYLEDRQTFRHSVVVPYEPPEAGSEYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKEVLCPELPPGSAKRALPTCTSASPPQKKKPLDGEYFTLKIRGRKRFEMFRELNEALELKDAHATEESGDSRAHSSYLKTKKGQSTSRHKKTMVKKVGPDSD
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