Tag |
Content |
Uniprot Accession |
P53_RAT; P10361; O09168; Q4KMA9; Q66HM0
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MiCroKit ID |
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Entrez ID |
24842
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Genbank Protein ID |
NP_112251.2; XP_006246656.1; XP_006246657.1
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Genbank Nucleotide ID |
NM_030989.3; XM_006246594.1; XM_006246595.1
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Protein Name |
Cellular tumor antigen p53; Tumor suppressor p53 |
Gene Name |
Tp53; P53 |
Organism |
Rattus norvegicus (Rat); NCBI Taxa ID=
10116 |
Localization |
Localization |
Evidence |
Orthologs |
Centrosome |
Predicted from orthologs |
(View/Close)
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Organism | Accession | Localization | Identity | E-value | Score |
Homo sapiens (Human) | P04637 |
Centrosome | 75.43% | 1e-167 | 585 | |
Functional Description |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the (View all)Functional Description
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation (By similarity).
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PTM Count: 0
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Sequence (Fasta) | MEDSQSDMSI ELPLSQETFS CLWKLLPPDD ILPTTATGSP NSMEDLFLPQ DVAELLEGPE EALQVSAPAA QEPGTEAPAP 80 VAPASATPWP LSSSVPSQKT YQGNYGFHLG FLQSGTAKSV MCTYSISLNK LFCQLAKTCP VQLWVTSTPP PGTRVRAMAI 160 YKKSQHMTEV VRRCPHHERC SDGDGLAPPQ HLIRVEGNPY AEYLDDRQTF RHSVVVPYEP PEVGSDYTTI HYKYMCNSSC 240 MGGMNRRPIL TIITLEDSSG NLLGRDSFEV RVCACPGRDR RTEEENFRKK EEHCPELPPG SAKRALPTST SSSPQQKKKP 320 LDGEYFTLKI RGRERFEMFR ELNEALELKD ARAAEESGDS RAHSSYPKTK KGQSTSRHKK PMIKKVGPDS D 391Fasta Sequence
>P10361|Tp53; P53|Rattus norvegicus (Rat) MEDSQSDMSIELPLSQETFSCLWKLLPPDDILPTTATGSPNSMEDLFLPQDVAELLEGPEEALQVSAPAAQEPGTEAPAPVAPASATPWPLSSSVPSQKTYQGNYGFHLGFLQSGTAKSVMCTYSISLNKLFCQLAKTCPVQLWVTSTPPPGTRVRAMAIYKKSQHMTEVVRRCPHHERCSDGDGLAPPQHLIRVEGNPYAEYLDDRQTFRHSVVVPYEPPEVGSDYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKEEHCPELPPGSAKRALPTSTSSSPQQKKKPLDGEYFTLKIRGRERFEMFRELNEALELKDARAAEESGDSRAHSSYPKTKKGQSTSRHKKPMIKKVGPDSD
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